Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.37 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 3/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6967685 | 0.85 | PRMT5 (0.47) | DHFRGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL6975482 | 0.82 | ALDH1A1 (0.39) | DHFRMAPK1DRD2KCNH2ALDH1A1 | |
| SCHEMBL6957984 | 0.80 | DRD2 (0.56) | DHFRGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL6965488 | 0.79 | MEN1 (0.45) | DHFRFAAHMAPK1DRD2KCNH2 | |
| SCHEMBL6970695 | 0.76 | DRD4 (0.46) | DHFRGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL6961877 | 0.74 | KMT2A (0.51) | ALDH1A1MEN1KMT2ADRD4DRD3 | |
| SCHEMBL6973388 | 0.74 | TMEM97 (0.60) | DHFRDRD2KCNH2MEN1KMT2A | |
| SCHEMBL6976524 | 0.73 | DHFR (0.46) | DHFRMAPK1DRD2ALDH1A1GAA | |
| SCHEMBL6967728 | 0.73 | CD44 (0.39) | DHFRMAPK1DRD2KCNH2ALDH1A1 | |
| SCHEMBL6973256 | 0.73 | MEN1 (0.47) | DRD2ALDH1A1MEN1KMT2ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1181954-A2 | Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (ApoB) secretion | PFIZER INC. (US) | 2002-02-27 | — | — | EP | disclosed |