Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1G | O43497 | 18/20 | 0.46 |
| ▸ | CACNA1H | O95180 | 18/20 | 0.46 |
| ▸ | CACNA1I | Q9P0X4 | 18/20 | 0.46 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5412525 | 0.81 | SMN1; SMN2 (0.47) | CACNA1GCACNA1HCACNA1IALDH1A1HTT | |
| SCHEMBL16347294 | 0.78 | CACNA1G (0.50) | CACNA1GCACNA1HCACNA1ICACNA1CALDH1A1 | |
| SCHEMBL27268228 | 0.77 | ALDH1A1 (0.39) | ALDH1A1 | |
| SCHEMBL17316676 | 0.76 | L3MBTL1 (0.65) | CACNA1GCACNA1HCACNA1ICACNA1CALDH1A1 | |
| SCHEMBL6078089 | 0.76 | CACNA1G (0.48) | CACNA1GCACNA1HCACNA1ICACNA1CALDH1A1 | |
| SCHEMBL18365943 | 0.75 | CACNA1G (0.59) | CACNA1GCACNA1HCACNA1ICACNA1C | |
| SCHEMBL30587615 | 0.75 | CACNA1G (0.59) | CACNA1GCACNA1HCACNA1ICACNA1C | |
| SCHEMBL30587614 | 0.75 | CACNA1G (0.59) | CACNA1GCACNA1HCACNA1ICACNA1C | |
| SCHEMBL16388102 | 0.75 | ALDH1A1 (0.62) | CACNA1GCACNA1HCACNA1IALDH1A1HTT | |
| SCHEMBL16347241 | 0.75 | HDAC1 (0.50) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3760625-A1 | BICYCLIC LACTAMS AS RECEPTOR-INTERACTING PROTEIN-1 (RIP1) KINASE INHIBITORS FOR TREATING E.G. INFLAMMATORY DISEASES | F. Hoffmann-La Roche AG (CH) | 2021-01-06 | — | — | EP | disclosed |
| WO-2017004500-A9 | BICYCLIC LACTAMS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | disclosed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | disclosed |
| EP-1202984-A1 | NOVEL DIPHENYL-PIPERIDINE DERIVATE | AstraZeneca UK Limited (GB) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001005782-A1 | NOVEL DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LIMITED (GB) | 2001-01-25 | — | — | WO | disclosed |