Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | FPR1 | P21462 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | ANXA2 | P07355 | 1/20 | 0.30 |
| ▸ | S100A10 | P60903 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7086390 | 0.91 | APLNR (0.34) | APLNRTDP1LMNA | |
| SCHEMBL7086752 | 0.89 | APLNR (0.33) | APLNRTDP1LMNAGAAMAPT | |
| SCHEMBL6970392 | 0.87 | APLNR (0.34) | APLNRTDP1LMNAGAAMAPT | |
| SCHEMBL6965321 | 0.87 | APLNR (0.34) | APLNRTDP1LMNAALDH1A1GAA | |
| SCHEMBL6976916 | 0.85 | DHODH (0.35) | — | |
| SCHEMBL6970602 | 0.84 | DHODH (0.31) | — | |
| SCHEMBL6961746 | 0.83 | ALDH1A1 (0.37) | ALDH1A1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL6969467 | 0.83 | ALDH1A1 (0.35) | APLNRTDP1LMNAALDH1A1TSHR | |
| SCHEMBL7081130 | 0.81 | ALDH1A1 (0.34) | APLNRTDP1LMNAALDH1A1TSHR | |
| SCHEMBL6966933 | 0.81 | TSHR (0.35) | APLNRTDP1LMNAALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |