Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.49 |
| ▸ | MME | P08473 | 6/20 | 0.46 |
| ▸ | MMP12 | P39900 | 2/20 | 0.45 |
| ▸ | ACE | P12821 | 5/20 | 0.44 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5870182 | 0.91 | FOLH1 (0.58) | FOLH1TSHRHTT | |
| SCHEMBL6955298 | 0.88 | FOLH1 (0.44) | FOLH1MMEMMP12LMNA | |
| SCHEMBL7179932 | 0.82 | FOLH1 (0.52) | FOLH1HTT | |
| SCHEMBL18576990 | 0.80 | FFAR1 (0.61) | FFAR1MMEACEABCC4LMNA | |
| SCHEMBL14866825 | 0.79 | IDO1 (0.47) | TSHR | |
| SCHEMBL27710469 | 0.78 | KDM4E (0.49) | FOLH1MMELMNAHTT | |
| SCHEMBL21572801 | 0.78 | LMNA (0.45) | MMEABCC4LMNAGAATSHR | |
| SCHEMBL14135221 | 0.77 | FFAR1 (0.50) | FOLH1FFAR1 | |
| SCHEMBL2608877 | 0.76 | IDO1 (0.52) | TSHR | |
| SCHEMBL31648059 | 0.76 | CPA3 (0.63) | FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358174-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002057248-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |