Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 4/20 | 0.59 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.44 |
| ▸ | HTR3B | O95264 | 2/20 | 0.44 |
| ▸ | HTR3A | P46098 | 2/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11879318 | 0.87 | HTR3E (0.56) | PLAUHTR3EHTR3BHTR3AHTR3D | |
| Nitric Acid SCHEMBL6033845 | 0.79 | ATM (0.44) | PLAUMEN1KMT2AF2PRSS1 | |
| Nitric Acid SCHEMBL1587377 | 0.79 | PLAU (0.59) | PLAUHTR3EHTR3BHTR3AHTR3D | |
| Nitric Acid SCHEMBL1587382 | 0.79 | PLAU (0.59) | PLAUHTR3EHTR3BHTR3AHTR3D | |
| Nitric Acid SCHEMBL28200213 | 0.76 | CES2 (0.41) | NPC1RAB9AMEN1KMT2AGAA | |
| Nitric Acid SCHEMBL4915048 | 0.75 | PLAU (0.54) | PLAUHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL11183085 | 0.74 | PLAU (1.00) | PLAUHTR3EHTR3BHTR3AHTR3D | |
| Phenylguanidine SCHEMBL6129042 | 0.73 | PLAU (0.71) | PLAUHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL11880304 | 0.72 | PLAU (0.54) | PLAUHTR3EHTR3BHTR3AHTR3D | |
| Nitric Acid SCHEMBL6034777 | 0.71 | PLAU (0.53) | PLAUHTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1274705-A1 | 2-SUBSTITUTED 4-HETEROARYL-PYRIMIDINES AND THEIR USE IN THE TREATMENT OF PROLIFERATIVE DISORDERS | Cyclacel Limited (GB) | 2003-01-15 | — | — | EP | disclosed |
| WO-2001072745-A1 | 2-SUBSTITUTED 4-HETEROARYL-PYRIMIDINES AND THEIR USE IN THE TREATMETN OF PROLIFERATIVE DISORDERS | CYCLACEL LIMITED (GB) | 2001-10-04 | — | — | WO | disclosed |