Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | POLB | P06746 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | RECQL | P46063 | 4/20 | 0.42 |
| ▸ | BLM | P54132 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | APEX1 | P27695 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.42 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.42 |
| ▸ | MYC | P01106 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6513076 | 0.79 | HSD17B1 (0.44) | KDM4EMAPTPOLBALDH1A1RECQL | |
| SCHEMBL18519888 | 0.78 | MAPT (0.47) | KDM4EMAPTPOLBALDH1A1RECQL | |
| SCHEMBL6954987 | 0.77 | PLOD2 (0.42) | KDM4EMAPTPOLBALDH1A1RECQL | |
| SCHEMBL3567606 | 0.77 | ESR1 (0.51) | KDM4EMAPTPOLBALDH1A1RECQL | |
| SCHEMBL6963436 | 0.77 | PTPN1 (0.49) | KDM4EMAPTPOLBALDH1A1HPGD | |
| SCHEMBL6770480 | 0.75 | ADORA2A (0.46) | KDM4EMAPTPOLBALDH1A1RECQL | |
| SCHEMBL6959703 | 0.73 | CFTR (0.51) | KDM4EMAPTPOLBALDH1A1RECQL | |
| SCHEMBL6765514 | 0.73 | ADORA1 (0.45) | KDM4EMAPTPOLBALDH1A1RECQL | |
| SCHEMBL6970043 | 0.71 | KDM4E (0.41) | KDM4EMAPTPOLBALDH1A1RECQL | |
| SCHEMBL31264118 | 0.71 | MEN1 (0.50) | KDM4EMAPTPOLBALDH1A1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6649636-B1 | Cyclooxygenase inhibitors | PFIZER INC. | 2003-11-18 | — | — | US | disclosed |
| EP-1104759-B1 | Heteroaryl phenyl pyrazole compounds as anti-inflammatory/analgesic agents | PFIZER PROD INC (US) | 2003-10-22 | — | — | EP | disclosed |
| EP-1104759-A1 | Heteroaryl phenyl pyrazole compounds as anti-inflammatory/analgesic agents | Pfizer Products Inc. (US) | 2001-06-06 | — | — | EP | disclosed |