Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.41 |
| ▸ | MEN1 | O00255 | 9/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.41 |
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | BLM | P54132 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6967431 | 0.77 | MAPT (0.37) | KDM4EALDH1A1HPGDMAPTMAPK1 | |
| SCHEMBL6963441 | 0.74 | PTPN1 (0.57) | KDM4EALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL3567606 | 0.74 | ESR1 (0.51) | KDM4EALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL6970040 | 0.71 | KDM4E (0.42) | KDM4EALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL6959707 | 0.71 | CFTR (0.49) | KDM4EALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL8476284 | 0.71 | MEN1 (0.50) | KDM4EALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL31264118 | 0.71 | MEN1 (0.50) | KDM4EALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL15196773 | 0.68 | TSHR (0.41) | KDM4EALDH1A1TSHR | |
| SCHEMBL4549089 | 0.68 | VCAM1 (0.46) | BLM | |
| SCHEMBL2975866 | 0.68 | TRPV4 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6649636-B1 | Cyclooxygenase inhibitors | PFIZER INC. | 2003-11-18 | — | — | US | disclosed |
| EP-1104759-B1 | Heteroaryl phenyl pyrazole compounds as anti-inflammatory/analgesic agents | PFIZER PROD INC (US) | 2003-10-22 | — | — | EP | disclosed |
| EP-1104759-A1 | Heteroaryl phenyl pyrazole compounds as anti-inflammatory/analgesic agents | Pfizer Products Inc. (US) | 2001-06-06 | — | — | EP | disclosed |