Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 2/20 | 0.31 |
| ▸ | CASP3 | P42574 | 2/20 | 0.31 |
| ▸ | CASP7 | P55210 | 2/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.31 |
| ▸ | GBA1 | P04062 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3274894 | 1.00 | PDK1 (0.31) | PDK1CASP3CASP7PDK2PDK3 | |
| SCHEMBL16511106 | 0.77 | CASP3 (0.39) | CASP3CASP7 | |
| SCHEMBL24272803 | 0.76 | CASP3 (0.33) | CASP3CASP7 | |
| SCHEMBL13696666 | 0.75 | SLC18A2 (0.30) | — | |
| SCHEMBL24272805 | 0.74 | GBA1 (0.33) | PDK1PDK2PDK3GBA1 | |
| SCHEMBL88691 | 0.74 | PDK1 (0.32) | PDK1PDK2PDK3 | |
| SCHEMBL13162844 | 0.74 | PDK1 (0.32) | PDK1PDK2PDK3 | |
| SCHEMBL12991681 | 0.74 | PAOX (0.35) | — | |
| SCHEMBL5222844 | 0.72 | ARG1 (0.46) | — | |
| SCHEMBL3282485 | 0.72 | ARG1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001094341-A9 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF TUMOURS | ASTRAZENECA AB (SE) | 2003-04-17 | — | — | WO | disclosed |
| EP-1292594-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF TUMOURS | AstraZeneca AB (SE) | 2003-03-19 | — | — | EP | disclosed |
| WO-2001094341-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF TUMOURS | ASTRAZENECA AB (SE) | 2001-12-13 | — | — | WO | disclosed |