Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30082667 | 0.91 | MEN1 (0.57) | MEN1NPC1RAB9AKMT2AHRH3 | |
| SCHEMBL6429540 | 0.85 | HSD11B1 (0.58) | MEN1NPC1RAB9AKMT2A | |
| SCHEMBL4961994 | 0.84 | SLC18A2 (0.55) | MEN1NPC1RAB9AKMT2ASLC18A2 | |
| SCHEMBL7482406 | 0.80 | DPP4 (0.45) | MEN1NPC1RAB9AKMT2AHRH3 | |
| SCHEMBL15264325 | 0.77 | MEN1 (0.46) | MEN1NPC1RAB9AKMT2ASLC18A2 | |
| SCHEMBL8541992 | 0.77 | NPC1 (0.64) | MEN1NPC1RAB9AKMT2AHRH3 | |
| SCHEMBL8543707 | 0.76 | NPC1 (0.62) | MEN1NPC1RAB9AKMT2AHRH3 | |
| SCHEMBL14646631 | 0.76 | NPC1 (0.70) | MEN1NPC1RAB9AKMT2AHRH3 | |
| SCHEMBL13086596 | 0.75 | KLK7 (0.49) | MEN1NPC1RAB9AKMT2ASLC18A2 | |
| SCHEMBL3046705 | 0.75 | KLK7 (0.49) | MEN1NPC1RAB9AKMT2ASLC18A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1060178-B1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER (US) | 2003-09-03 | — | — | EP | disclosed |