Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.58 |
| ▸ | DPP4 | P27487 | 1/20 | 0.56 |
| ▸ | DAGLA | Q9Y4D2 | 12/20 | 0.55 |
| ▸ | ABHD6 | Q9BV23 | 8/20 | 0.55 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.51 |
| ▸ | DAGLB | Q8NCG7 | 2/20 | 0.51 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.50 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.50 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.50 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.50 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5800629 | 0.89 | TACR1 (0.46) | HSD11B1DPP4DAGLAABHD6SCD5 | |
| SCHEMBL4964339 | 0.88 | HSD11B1 (0.61) | HSD11B1DPP4DAGLAABHD6MEN1 | |
| SCHEMBL4629395 | 0.88 | HSD11B1 (0.61) | HSD11B1DPP4DAGLAABHD6MEN1 | |
| Hydrochloric Acid SCHEMBL29238125 | 0.86 | HSD11B1 (0.60) | HSD11B1DPP4DAGLAABHD6MEN1 | |
| SCHEMBL6970610 | 0.85 | MEN1 (0.54) | MEN1NPC1RAB9AKMT2A | |
| SCHEMBL27651068 | 0.85 | HSD11B1 (0.58) | HSD11B1DPP4DAGLAABHD6MEN1 | |
| SCHEMBL21138521 | 0.85 | HSD11B1 (0.62) | HSD11B1DPP4DAGLAABHD6MEN1 | |
| SCHEMBL11481440 | 0.84 | HSD11B1 (0.57) | HSD11B1DPP4DAGLAABHD6MEN1 | |
| SCHEMBL23459127 | 0.83 | SCD5 (0.57) | HSD11B1DPP4DAGLAABHD6MEN1 | |
| SCHEMBL908981 | 0.83 | SCD5 (0.57) | HSD11B1DPP4DAGLAABHD6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2668157-A1 | PROTEASE ACTIVATED RECEPTOR 2 (PAR2) ANTAGONISTS | Proximagen Limited (GB) | 2013-12-04 | — | — | EP | disclosed |
| WO-2012101453-A1 | PROTEASE ACTIVATED RECEPTOR 2 (PAR2) ANTAGONISTS | PROXIMAGEN LTD. (GB) | 2012-08-02 | — | — | WO | disclosed |
| EP-1585749-A1 | DIAZEPINOINDOLE DERIVATIVES AS KINASE INHIBITORS | PFIZER INC. (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004063198-A1 | DIAZEPINOINDOLE DERIVATIVES AS KINASE INHIBITORS | PFIZER INC. (US) | 2004-07-29 | — | — | WO | disclosed |
| EP-0351283-A1 | 2-[(4-Piperidinyl)methyl]-2,3-dihydro-1H-isoindole and 2,3,4,5-tetrahydro-1H-benzazepine derivatives, their preparation and therapeutical use | SYNTHELABO (FR) | 1990-01-17 | — | — | EP | disclosed |