Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | IL1B | P01584 | 1/20 | 0.30 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.30 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7081079 | 0.94 | HSP90B1 (0.33) | HRH1HSP90B1TRAP1 | |
| SCHEMBL6966452 | 0.92 | HRH1 (0.32) | HRH1P2RX7GABRA5IL1BHSP90B1 | |
| SCHEMBL7087627 | 0.89 | ENPP2 (0.31) | GABRA5 | |
| SCHEMBL7081352 | 0.86 | TDP1 (0.31) | HSP90B1TRAP1 | |
| SCHEMBL6969765 | 0.85 | SMN1; SMN2 (0.31) | — | |
| SCHEMBL6969846 | 0.85 | KDM4E (0.33) | HSP90B1TRAP1 | |
| SCHEMBL7082531 | 0.85 | HRH1 (0.34) | HRH1HSP90B1TRAP1 | |
| SCHEMBL6965901 | 0.84 | RAB9A (0.35) | — | |
| SCHEMBL6975013 | 0.83 | ENPP2 (0.30) | — | |
| SCHEMBL6967282 | 0.83 | TDP1 (0.32) | GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |