Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | GCGR | P47871 | 1/20 | 0.32 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.31 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6968855 | 0.94 | ALDH1A1 (0.36) | KDM4EALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL6960543 | 0.92 | GCGR (0.33) | KDM4EALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL6965285 | 0.88 | GCGR (0.30) | GCGR | |
| SCHEMBL6964951 | 0.86 | ALDH1A1 (0.32) | KDM4EALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL6957642 | 0.85 | ALDH1A1 (0.34) | KDM4EALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL6961597 | 0.85 | HSP90B1 (0.32) | KDM4EALDH1A1HPGDSMN1; SMN2HSP90B1 | |
| SCHEMBL6970972 | 0.85 | HRH1 (0.31) | HSP90B1TRAP1 | |
| SCHEMBL7083579 | 0.84 | ALDH1A1 (0.32) | ALDH1A1TDP1 | |
| SCHEMBL6972629 | 0.84 | AGTR1 (0.37) | KDM4EALDH1A1LMNATDP1 | |
| SCHEMBL6969515 | 0.83 | TLR7 (0.35) | KDM4EALDH1A1LMNAHPGDHSP90B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |