Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | SPR | P35270 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6969073 | 0.80 | KMT2A (0.55) | KMT2AMAPK1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7240740 | 0.80 | MAPK1 (0.50) | KMT2AMEN1MAPK1TSHRSPR | |
| SCHEMBL7233788 | 0.74 | MAPK1 (0.51) | KMT2AMAPK1SPRSMN1; SMN2ALDH1A1 | |
| SCHEMBL6971187 | 0.73 | MAPK1 (0.54) | KMT2ACYP1A2MAPK1SPRSMN1; SMN2 | |
| SCHEMBL20646803 | 0.71 | MAPK1 (0.58) | KMT2AMAPK1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL8689373 | 0.70 | CYP1A2 (0.64) | KMT2AMEN1CYP1A2MAPK1TSHR | |
| SCHEMBL6962499 | 0.70 | MAPK1 (0.61) | KMT2ACYP1A2MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL882663 | 0.69 | CYP1A2 (0.52) | KMT2AMEN1CYP1A2MAPK1TSHR | |
| SCHEMBL18711819 | 0.69 | SPR (0.80) | SPR | |
| SCHEMBL7240851 | 0.67 | MAPK1 (0.49) | KMT2ACYP1A2MAPK1SPRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784055-B1 | PYRIMIDINYLPYRAZOLE DERIVATIVE | DAIICHI SEIYAKU CO (JP) | 2003-02-12 | — | — | EP | disclosed |
| US-5852019-A | Pyrimidinylpyrazole derivatives | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1998-12-22 | — | — | US | disclosed |
| EP-0784055-A1 | PYRIMIDINYLPYRAZOLE DERIVATIVE | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1997-07-16 | — | — | EP | disclosed |