Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6975039 | 0.95 | TBXAS1 (0.36) | PTGDR2GRM2TBXAS1TBXA2RGRIN1 | |
| SCHEMBL6977996 | 0.90 | MCL1 (0.39) | GRM2TBXAS1PLA2G7 | |
| SCHEMBL1961296 | 0.90 | GABRA1 (0.36) | GRM2TBXAS1PLA2G7CYP1A2CYP3A4 | |
| SCHEMBL6970863 | 0.89 | CYP1A2 (0.39) | PLA2G7CYP11B1CYP11B2LMNACYP1A2 | |
| SCHEMBL6973785 | 0.89 | CYP11B1 (0.35) | TBXAS1TBXA2RGRIN1GRIN2BCYP11B1 | |
| Hydrochloric Acid SCHEMBL6977314 | 0.89 | GABRA1 (0.36) | TBXAS1PLA2G7CYP1A2CYP3A4CYP2C9 | |
| Hydrochloric Acid SCHEMBL6973682 | 0.89 | MCL1 (0.39) | GRM2TBXAS1PLA2G7 | |
| Hydrochloric Acid SCHEMBL6979332 | 0.88 | CYP11B1 (0.35) | TBXAS1TBXA2RGRIN1GRIN2BCYP11B1 | |
| SCHEMBL6975041 | 0.88 | PTGDR2 (0.34) | PTGDR2GRM2TBXAS1GRIN1GRIN2B | |
| Sulfuric Acid SCHEMBL6983443 | 0.87 | GABRA1 (0.35) | TBXAS1PLA2G7CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0985671-B1 | PYRIDOCARBAZOLE DERIVATIVES HAVING cGMP-PDE INHIBITORY EFFECT | MOCHIDA PHARM CO LTD (JP) | 2003-04-02 | — | — | EP | disclosed |
| US-6197768-B1 | THERAPY, PREVENTION ISCHEMIC HEART DISEASE | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-06 | — | — | US | disclosed |
| EP-0985671-A1 | PYRIDOCARBAZOLE DERIVATIVES HAVING cGMP-PDE INHIBITORY EFFECT | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2000-03-15 | — | — | EP | disclosed |
| US-6018046-A | SELECTIVE ACTION IN INHIBITING CYCLIC GMP-PHOSPHODIESTERASE (CGMP-PDE); PHARMACEUTICALS FOR TREATING DISEASES AGAINST WHICH THE INHIBITORY ACTION IS EFFECTIVE, SUCH AS PULMONARY HYPERTENSION | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2000-01-25 | — | — | US | disclosed |