SCHEMBL6971095

SCHEMBL6971095

Cc1ccc(S(=O)(=O)OC[C@H]2COc3cccc(Cl)c3O2)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 1/20 0.54
LMNA P02545 4/20 0.46
FFAR1 O14842 2/20 0.45
SMN1; SMN2 Q16637 2/20 0.43
ADRA1D P25100 2/20 0.43
ADRA1A P35348 2/20 0.43
ADRA1B P35368 2/20 0.43
ALDH1A1 P00352 2/20 0.40
CYP3A4 P08684 2/20 0.40
CYP2D6 P10635 2/20 0.40
TSHR P16473 2/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
MAPT P10636 1/20 0.40
MAPK1 P28482 1/20 0.40
PRMT5 O14744 1/20 0.37
WDR77 Q9BQA1 1/20 0.37
POLB P06746 1/20 0.36
RAB9A P51151 1/20 0.36
MEN1 O00255 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6971100 1.00 CA2 (0.54) CA2LMNAFFAR1SMN1; SMN2ADRA1D
SCHEMBL9372518 0.91 LMNA (0.46) CA2LMNAFFAR1SMN1; SMN2ADRA1D
SCHEMBL4962952 0.91 LMNA (0.44) CA2LMNAFFAR1SMN1; SMN2ADRA1D
SCHEMBL4960403 0.91 LMNA (0.44) CA2LMNAFFAR1SMN1; SMN2ADRA1D
SCHEMBL4962935 0.91 CA2 (0.44) CA2LMNAFFAR1SMN1; SMN2ADRA1D
SCHEMBL4962357 0.90 CA2 (0.43) CA2LMNAFFAR1SMN1; SMN2ADRA1D
SCHEMBL6976444 0.90 LMNA (0.48) CA2LMNASMN1; SMN2ALDH1A1CYP3A4
SCHEMBL7782073 0.90 LMNA (0.48) CA2LMNASMN1; SMN2ALDH1A1CYP3A4
SCHEMBL6976439 0.90 LMNA (0.48) CA2LMNASMN1; SMN2ALDH1A1CYP3A4
SCHEMBL1021389 0.87 LMNA (0.46) CA2LMNASMN1; SMN2ADRA1DADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0839145-B1 HETEROCYCLYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS ABBOTT GMBH & CO KG (DE) 2003-11-05 EP disclosed
US-5935973-A AFFINITY FOR 5-HT1A, ALPHA1, ALPHA2 AND/OR D2 RECEPTORS; ANTIDEPRESSANTS, ANXIOLYTIC AGENTS, PSYCHOSES, DYSKINESIAS, PARKINSON'S DISEASE, HYPOTENSIVE AGENTS, TOURETTE'S SYNDROME, OBSESSIVE-COMPULSIVE BEHAVIOUR, PANIC ATTACKS, SOCIAL PHOBIAS KNOLL AKTIENGESELLSCHAFT (DE) 1999-08-10 US disclosed
EP-0839145-A1 HETEROCYCLYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS Knoll AG (DE) 1998-05-06 EP disclosed
WO-1997003071-A1 HETEROCYCLYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS KNOLL AKTIENGESELLSCHAFT (DE) 1997-01-30 WO disclosed