Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 4/20 | 0.44 |
| ▸ | CA1 | P00915 | 4/20 | 0.44 |
| ▸ | CA2 | P00918 | 4/20 | 0.44 |
| ▸ | CA7 | P43166 | 4/20 | 0.44 |
| ▸ | CA9 | Q16790 | 4/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6299118 | 0.83 | GAA (0.51) | GAANPC1POLBCA12CA1 | |
| SCHEMBL14764650 | 0.83 | GABRA1 (0.46) | GAAPOLBALDH1A1KDM4EHSD17B10 | |
| SCHEMBL6179423 | 0.81 | GAA (0.49) | GAANPC1POLBCA12CA1 | |
| SCHEMBL10469464 | 0.78 | GABRA1 (0.41) | GAAPOLBALDH1A1KDM4EMAPT | |
| SCHEMBL11561649 | 0.76 | AKR1C2 (0.47) | POLBALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL23796484 | 0.76 | CA12 (0.65) | GAACA12CA1CA2CA7 | |
| SCHEMBL4625676 | 0.76 | TSHR (0.56) | GAANPC1CA12CA1CA2 | |
| SCHEMBL15724964 | 0.74 | CA12 (0.51) | NPC1CA12CA1CA2CA7 | |
| SCHEMBL7933917 | 0.74 | ESR1 (0.41) | ALDH1A1KDM4EHSD17B10HPGDNR5A2 | |
| SCHEMBL4239107 | 0.73 | TSHR (0.63) | GAANPC1POLBCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0902007-B1 | CHALCONE DERIVATIVES AND DRUGS CONTAINING THE SAME | KOWA CO (JP) | 2003-11-05 | — | — | EP | disclosed |
| US-6046212-A | ANTIALLERGIC AGENTS | KOWA CO., LTD. (JP) | 2000-04-04 | — | — | US | disclosed |
| EP-0902007-A1 | CHALCONE DERIVATIVES AND DRUGS CONTAINING THE SAME | KOWA CO. LTD. (JP) | 1999-03-17 | — | — | EP | disclosed |