Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 10/20 | 0.53 |
| ▸ | F13A1 | P00488 | 7/20 | 0.53 |
| ▸ | TGM1 | P22735 | 4/20 | 0.53 |
| ▸ | RORC | P51449 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
| ▸ | GPR183 | P32249 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL710366 | 0.89 | TGM2 (0.64) | TGM2F13A1TGM1GPR183PKM | |
| SCHEMBL6977155 | 0.85 | TGM2 (0.62) | TGM2F13A1TGM1GPR183PKM | |
| SCHEMBL14490210 | 0.84 | TGM2 (0.59) | TGM2F13A1TGM1GPR183PKM | |
| SCHEMBL6977995 | 0.81 | TGM2 (0.58) | TGM2F13A1TGM1 | |
| SCHEMBL27527433 | 0.81 | RORC (0.39) | TGM2F13A1TGM1RORCGPR119 | |
| SCHEMBL6980123 | 0.80 | LSS (0.60) | TGM2F13A1TGM1PKM | |
| SCHEMBL7086266 | 0.78 | ALDH1A1 (0.59) | TGM2F13A1TGM1PKM | |
| SCHEMBL5736659 | 0.78 | F10 (0.57) | TGM2F13A1TGM1PKM | |
| SCHEMBL18410584 | 0.78 | TGM2 (0.65) | TGM2F13A1TGM1PKM | |
| SCHEMBL6974195 | 0.77 | EPHX2 (0.53) | TGM2F13A1TGM1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925286-B1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ASTRAZENECA AB (SE) | 2003-01-02 | — | — | EP | disclosed |
| US-6093718-A | AN OXIDO-SQUALENE CYCLASE INHIBITOR, ANTICHOLESTEROL AGENT FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND LOWERING CHOLESTEROL LEVELS IN BLOOD PLASMA; TREATING HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2000-07-25 | — | — | US | disclosed |
| EP-0925286-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1999-06-30 | — | — | EP | disclosed |
| WO-1998006705-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1998-02-19 | — | — | WO | disclosed |