Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 7/20 | 0.53 |
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981057 | 0.80 | ALDH1A1 (0.53) | GAAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL6977827 | 0.76 | DEPTOR (0.53) | GAAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL7921590 | 0.75 | TUBB4A (0.44) | GAAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL2776448 | 0.73 | MAPT (0.58) | GAAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL6971595 | 0.72 | MAPT (0.53) | GAAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL924770 | 0.72 | NR4A1 (0.46) | GAAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL26512355 | 0.71 | GAA (0.39) | GAAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL13576584 | 0.70 | PIM1 (0.46) | GAAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL8856666 | 0.70 | SENP6 (0.61) | GAAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL31491993 | 0.70 | KDR (0.48) | GAAMAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6214813-B1 | AZOPYRAZOLES | KINETEK PHARMACEUTICALS, INC. (CA) | 2001-04-10 | — | — | US | claimed |
| EP-1276723-A2 | PYRAZOLE COMPOUNDS HAVING ANTI PROLIFERATIVE ACTIVITY | Kinetek Pharmaceuticals, Inc. (CA) | 2003-01-22 | — | — | EP | disclosed |
| US-6436915-B1 | ANTIPROLIFERATIVE AND ANTITUMOR AGENTS AND ANGIOGENESIS INHIBITORS | KINETEK PHARMACEUTICALS, INC. (CA) | 2002-08-20 | — | — | US | disclosed |
| US-20020042501-A1 | Pyrazole compounds | DERMIRA (CANADA), INC. | 2002-04-11 | — | — | US | disclosed |
| WO-2001077080-A2 | PYRAZOLE COMPOUNDS HAVING ANTI PROLIFERATIVE ACTIVITY | KINETEK PHARMACEUTICALS, INC. (CA) | 2001-10-18 | — | — | WO | disclosed |
| US-6214813-B1 | AZOPYRAZOLES | KINETEK PHARMACEUTICALS, INC. (CA) | 2001-04-10 | — | — | US | disclosed |