Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | GCGR | P47871 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6975218 | 0.90 | SMN1; SMN2 (0.36) | SMN1; SMN2GCGRKMT2AMEN1POLB | |
| SCHEMBL6968809 | 0.87 | ALDH1A1 (0.38) | SMN1; SMN2GCGRKMT2AMEN1TSHR | |
| SCHEMBL6965584 | 0.86 | MEN1 (0.35) | SMN1; SMN2GCGRKMT2AMEN1LMNA | |
| SCHEMBL6967197 | 0.86 | SLC6A4 (0.34) | SMN1; SMN2GCGRKMT2AMEN1LMNA | |
| SCHEMBL6961885 | 0.85 | TP53 (0.37) | KMT2AMEN1DHODHPOLBNPSR1 | |
| SCHEMBL6974771 | 0.85 | DHODH (0.43) | GCGRKMT2ADHODHATMLMNA | |
| SCHEMBL7086624 | 0.84 | ACSS2 (0.34) | SMN1; SMN2GCGRTSHRATM | |
| SCHEMBL7082939 | 0.84 | SMN1; SMN2 (0.31) | SMN1; SMN2LMNASLC6A4ALDH1A1MAPT | |
| SCHEMBL7084256 | 0.84 | SMN1; SMN2 (0.35) | SMN1; SMN2TSHRLMNASLC6A4ALDH1A1 | |
| SCHEMBL6972514 | 0.84 | HTR2C (0.35) | SMN1; SMN2KMT2AMEN1LMNASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |