Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 6/20 | 0.35 |
| ▸ | BRD9 | Q9H8M2 | 6/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | BRD2 | P25440 | 3/20 | 0.33 |
| ▸ | BRD7 | Q9NPI1 | 3/20 | 0.33 |
| ▸ | PGK1 | P00558 | 1/20 | 0.32 |
| ▸ | PGK2 | P07205 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6962732 | 0.82 | ALDH1A1 (0.36) | HPGDHSD17B10MCL1PGK1PGK2 | |
| SCHEMBL30631691 | 0.80 | HPGD (0.40) | HPGDHSD17B10MCL1PGK1PGK2 | |
| SCHEMBL18077441 | 0.79 | HPGD (0.39) | HPGDHSD17B10PGK1PGK2ALDH1A1 | |
| SCHEMBL6966666 | 0.77 | HPGD (0.38) | HPGDHSD17B10PGK1PGK2ALDH1A1 | |
| SCHEMBL8625037 | 0.77 | HPGD (0.41) | HPGDHSD17B10PGK1PGK2KDM4E | |
| SCHEMBL30411660 | 0.77 | HPGD (0.38) | HPGDHSD17B10PGK1PGK2ALDH1A1 | |
| SCHEMBL9806987 | 0.76 | HPGD (0.36) | HPGDHSD17B10PGK1PGK2KDM4E | |
| SCHEMBL22599825 | 0.76 | HSD17B10 (0.37) | HPGDHSD17B10PGK1PGK2ALDH1A1 | |
| SCHEMBL6551606 | 0.75 | CYP3A4 (0.38) | HPGDHSD17B10MCL1KDM4EALDH1A1 | |
| SCHEMBL20934702 | 0.73 | HPGD (0.31) | HPGDHSD17B10MAOBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1145623-C | Imidazole derivatives | - | 2004-04-14 | — | — | CN | disclosed |
| EP-0797575-B1 | IMIDAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS IN PARTICULAR EGF-R TYROSINE KINASE | HOFFMANN LA ROCHE (CH) | 2003-10-15 | — | — | EP | disclosed |
| US-5959113-A | REACTING A DIKETONE DERIVATIVE WITH AN ALDEHYDE DERIVATIVE; ADMINISTERING TO TREAT ATHEROSCLEROSIS, PSORIASIS, ALOPECIA AND TUMORS | HOFFMANN-LA ROCHE INC. (US) | 1999-09-28 | — | — | US | disclosed |
| CN-1175252-A | Imidazole derivatives as protein kinase inhibitors in particular egf-rthyrosine kinase | HOFFMANN LA ROCHE (CH) | 1998-03-04 | — | — | CN | disclosed |
| EP-0797575-A1 | IMIDAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS IN PARTICULAR EGF-R TYROSINE KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 1997-10-01 | — | — | EP | disclosed |
| WO-1996018626-A1 | IMIDAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS IN PARTICULAR EGF-R TYROSINE KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 1996-06-20 | — | — | WO | disclosed |