Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 5/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 2/20 | 0.37 |
| ▸ | XPO1 | O14980 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7137847 | 0.84 | LMNA (0.42) | LMNAMAPTPPARGCNR1EPHX2 | |
| SCHEMBL6970913 | 0.84 | OPRM1 (0.45) | OPRM1LMNAABCB11MAPTMAPK1 | |
| SCHEMBL6979573 | 0.83 | OPRM1 (0.49) | OPRM1LMNAABCB11MAPTMAPK1 | |
| SCHEMBL6981778 | 0.83 | OPRM1 (0.42) | OPRM1 | |
| SCHEMBL6971194 | 0.81 | OPRM1 (0.45) | OPRM1LMNAABCB11MAPTMAPK1 | |
| SCHEMBL7819154 | 0.81 | CNR1 (0.36) | OPRM1LMNAABCB11MAPTMAPK1 | |
| SCHEMBL6982866 | 0.77 | OPRM1 (0.41) | OPRM1LMNAABCB11MAPTMAPK1 | |
| SCHEMBL6978137 | 0.76 | OPRM1 (0.43) | OPRM1LMNAABCB11MAPTMAPK1 | |
| SCHEMBL6978140 | 0.76 | OPRM1 (0.49) | OPRM1 | |
| SCHEMBL6974990 | 0.76 | OPRM1 (0.46) | OPRM1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098893-B1 | CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | disclosed |