Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 1/20 | 0.58 |
| ▸ | FLT4 | P35916 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | CES2 | O00748 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8866483 | 0.85 | CYP3A4 (0.59) | FLT1FLT4KDRCYP3A4CYP2C19 | |
| SCHEMBL6971828 | 0.85 | FLT1 (0.57) | FLT1FLT4KDRCYP3A4CYP2C19 | |
| SCHEMBL1176899 | 0.85 | CTSD (0.63) | FLT1FLT4KDRCYP3A4CYP2C19 | |
| SCHEMBL9692669 | 0.84 | CES2 (0.61) | FLT1FLT4KDRCYP3A4CYP2C19 | |
| SCHEMBL11459254 | 0.82 | CES2 (0.59) | FLT1FLT4KDRCYP3A4CYP2C19 | |
| SCHEMBL30302454 | 0.82 | KMT2A (0.72) | CYP3A4CYP2C19MAPTPOLBMEN1 | |
| SCHEMBL5341177 | 0.82 | CES2 (0.63) | FLT1FLT4KDRCYP3A4CYP2C19 | |
| SCHEMBL27848157 | 0.82 | LMNA (0.61) | FLT1FLT4KDRCYP3A4CYP2C19 | |
| SCHEMBL503450 | 0.80 | CES2 (0.66) | CYP3A4CES2MAPTPOLBMEN1 | |
| SCHEMBL15610402 | 0.80 | LMNA (0.56) | FLT1FLT4KDRCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |