Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | UBE2N | P61088 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL161002 | 0.80 | HDAC8 (0.48) | SMN1; SMN2GAAHTTHPGD | |
| SCHEMBL158021 | 0.79 | GAA (0.41) | ALDH1A1SMN1; SMN2GAALMNAMEN1 | |
| SCHEMBL7081396 | 0.79 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2GAARAB9ANPC1 | |
| SCHEMBL3363210 | 0.78 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2GAARAB9ANPC1 | |
| SCHEMBL687760 | 0.77 | MAPT (0.46) | ALDH1A1SMN1; SMN2GAARAB9ANPC1 | |
| SCHEMBL10716721 | 0.77 | KDM4E (0.48) | ALDH1A1GAALMNAHTTMAPT | |
| SCHEMBL1490709 | 0.77 | L3MBTL1 (0.55) | ALDH1A1SMN1; SMN2GAARAB9ANPC1 | |
| SCHEMBL2883020 | 0.76 | TSHR (0.38) | ALDH1A1SMN1; SMN2RAB9ANPC1HTT | |
| SCHEMBL6665089 | 0.75 | RAB9A (0.42) | ALDH1A1SMN1; SMN2GAARAB9ANPC1 | |
| SCHEMBL6159654 | 0.74 | HDAC6 (0.56) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |