Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 7/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6967887 | 0.95 | LMNA (0.35) | LMNAPPARGTLR7TDP1 | |
| SCHEMBL6961399 | 0.92 | PPARG (0.35) | LMNAPPARGTLR7KCNH2AGTR1 | |
| SCHEMBL6965758 | 0.92 | ENPP2 (0.34) | LMNAPPARGTLR7KCNH2AGTR1 | |
| SCHEMBL7085936 | 0.92 | LMNA (0.42) | LMNAPPARG | |
| SCHEMBL6974575 | 0.92 | TLR7 (0.35) | LMNAPPARGTLR7KCNH2TDP1 | |
| SCHEMBL6969841 | 0.91 | LMNA (0.44) | LMNAPPARGGSK3B | |
| SCHEMBL6970826 | 0.91 | GRIN1 (0.35) | LMNATLR7 | |
| SCHEMBL6975529 | 0.90 | LMNA (0.41) | LMNAPPARGTLR7KCNH2TDP1 | |
| SCHEMBL6975183 | 0.89 | ENPP2 (0.35) | LMNATLR7TDP1 | |
| SCHEMBL6967565 | 0.89 | LMNA (0.32) | LMNAPPARGTLR7AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |