Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 7/20 | 0.61 |
| ▸ | MMP3 | P08254 | 7/20 | 0.61 |
| ▸ | MMP1 | P03956 | 2/20 | 0.60 |
| ▸ | MMP9 | P14780 | 2/20 | 0.60 |
| ▸ | MMP14 | P50281 | 2/20 | 0.60 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6434601 | 0.90 | MMP2 (0.48) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL6437356 | 0.89 | MMP2 (0.50) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL6437057 | 0.89 | MMP2 (0.47) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL6972911 | 0.76 | MMP2 (0.42) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL6587767 | 0.76 | MMP2 (0.79) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL6584994 | 0.76 | MMP2 (0.85) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL6585076 | 0.76 | MMP3 (1.00) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL6584490 | 0.75 | MMP3 (0.71) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL6585851 | 0.75 | MMP3 (1.00) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL6584000 | 0.75 | MMP3 (0.61) | MMP2MMP3MMP1MMP9MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1181017-B1 | METALLOPROTEASE INHIBITORS | PFIZER LTD (GB) | 2003-04-16 | — | — | EP | claimed |