Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.55 |
| ▸ | KCNK3 | O14649 | 4/20 | 0.52 |
| ▸ | KCNK9 | Q9NPC2 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | DDX3X | O00571 | 1/20 | 0.49 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.48 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11858223 | 0.89 | GPR35 (0.67) | GPR35KCNK3KCNK9MEN1KMT2A | |
| SCHEMBL4714652 | 0.83 | HSD17B10 (0.71) | MEN1KMT2AHSD17B10POLBMAPT | |
| SCHEMBL1487964 | 0.83 | ALDH1A1 (0.66) | MEN1KMT2AHSD17B10POLBMAPT | |
| SCHEMBL16488795 | 0.82 | MEN1 (0.51) | GPR35MEN1KMT2AHSD17B10POLB | |
| SCHEMBL8350546 | 0.82 | GAA (0.50) | GPR35KCNK3KCNK9HSD17B10POLB | |
| SCHEMBL23577148 | 0.81 | KCNK3 (0.82) | KCNK3KCNK9MEN1KMT2APOLB | |
| SCHEMBL692386 | 0.81 | HSD17B10 (0.74) | KCNK3KCNK9MEN1KMT2AHSD17B10 | |
| SCHEMBL30762995 | 0.81 | HSD17B10 (0.74) | KCNK3KCNK9MEN1KMT2AHSD17B10 | |
| SCHEMBL17518820 | 0.80 | MAPK1 (0.55) | GPR35KCNK3KCNK9MEN1KMT2A | |
| SCHEMBL20057565 | 0.80 | TP53 (0.60) | MEN1KMT2AHSD17B10POLBDDX3X |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103936716-B | Tool muscarinic receptor antagonists and the diamide compound of beta 2 adrenoreceptor agonists activity | 施万呼吸有限责任公司 | 2016-09-07 | — | — | CN | disclosed |
| EP-2421849-A1 | DIAMIDE COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY | Theravance, Inc. (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010123766-A1 | DIAMIDE COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND β2 ADRENERGIC RECEPTOR AGONIST ACTIVITY | THERAVANCE, INC. (US) | 2010-10-28 | — | — | WO | disclosed |