Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 10/20 | 0.68 |
| ▸ | MMP3 | P08254 | 10/20 | 0.68 |
| ▸ | MMP1 | P03956 | 2/20 | 0.68 |
| ▸ | MMP9 | P14780 | 2/20 | 0.68 |
| ▸ | MMP14 | P50281 | 2/20 | 0.68 |
| ▸ | PRMT5 | O14744 | 5/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 2/20 | 0.35 |
| ▸ | USP5 | P45974 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6971949 | 1.00 | MMP2 (0.68) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL7538112 | 0.93 | MMP2 (0.68) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL6436523 | 0.93 | MMP2 (0.68) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL6956464 | 0.92 | MMP3 (0.81) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL7432313 | 0.91 | MMP2 (0.66) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL6433752 | 0.91 | MMP2 (0.66) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL6440700 | 0.89 | MMP2 (0.71) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL6587846 | 0.89 | MMP2 (0.83) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL6586333 | 0.87 | MMP2 (0.85) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL6436990 | 0.86 | MMP3 (0.69) | MMP2MMP3MMP1MMP9MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1181017-B1 | METALLOPROTEASE INHIBITORS | PFIZER LTD (GB) | 2003-04-16 | — | — | EP | disclosed |
| US-6511993-B1 | Substituted alpha-aminosulphonyl-acetohydroxamic acids which are inhibitors of zinc-dependent metalloprotease enzymes | PFIZER INC. | 2003-01-28 | — | — | US | disclosed |
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| EP-1181017-A1 | METALLOPROTEASE INHIBITORS | Pfizer Limited (GB) | 2002-02-27 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |
| WO-2000074681-A1 | METALLOPROTEASE INHIBITORS | PFIZER LIMITED (GB) | 2000-12-14 | — | — | WO | disclosed |