Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 12/20 | 0.57 |
| ▸ | DRD2 | P14416 | 7/20 | 0.57 |
| ▸ | DRD5 | P21918 | 4/20 | 0.57 |
| ▸ | HTR1A | P08908 | 2/20 | 0.53 |
| ▸ | HTR7 | P34969 | 2/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.50 |
| ▸ | DRD1 | P21728 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6712934 | 0.99 | DRD3 (0.56) | DRD3DRD2DRD5HTR1AHTR7 | |
| SCHEMBL6711558 | 0.83 | DRD3 (0.56) | DRD3DRD2DRD5HTR1AHTR7 | |
| SCHEMBL9725137 | 0.83 | HTR1A (0.55) | DRD3DRD2HTR1AHTR7OPRM1 | |
| SCHEMBL6711653 | 0.80 | DRD3 (0.62) | DRD3DRD2DRD5HTR1AHTR7 | |
| SCHEMBL6716162 | 0.79 | DRD3 (0.69) | DRD3DRD2DRD5HTR1AHTR7 | |
| SCHEMBL29799616 | 0.79 | HTR1A (0.65) | DRD3DRD2HTR1AHTR7OPRM1 | |
| SCHEMBL9725084 | 0.79 | HTR1A (0.65) | DRD3DRD2HTR1AHTR7OPRM1 | |
| SCHEMBL7082370 | 0.77 | DRD3 (0.56) | DRD3DRD2DRD5HTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL6715836 | 0.77 | DRD3 (0.55) | DRD3DRD2DRD5HTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL6719032 | 0.76 | DRD3 (0.50) | DRD3DRD2DRD5HTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296954-A1 | BICYCLIC LACTAMS AND SULFONAMIDES WITH 5-HT1A-AFFINITY AND USE THEREOF FOR PREVENTING AND TREATING CEREBRAL ISCHAEMIA | Abbott GmbH & Co. KG (DE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002002529-A1 | BICYCLIC LACTAMS AND SULFONAMIDES WITH 5-HT1A-AFFINITY AND USE THEREOF FOR PREVENTING AND TREATING CEREBRAL ISCHAEMIA | ABBOTT GMBH & CO. KG (DE) | 2002-01-10 | — | — | WO | disclosed |