Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.55 |
| ▸ | DRD2 | P14416 | 5/20 | 0.54 |
| ▸ | DRD3 | P35462 | 4/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9725084 | 0.93 | HTR1A (0.65) | HTR1ADRD2DRD3OPRM1HTR2A | |
| SCHEMBL29799616 | 0.93 | HTR1A (0.65) | HTR1ADRD2DRD3OPRM1HTR2A | |
| SCHEMBL14762253 | 0.84 | HTR1A (0.58) | HTR1ADRD2DRD3LMNANPSR1 | |
| SCHEMBL6972081 | 0.83 | DRD3 (0.57) | HTR1ADRD2DRD3OPRM1HTR7 | |
| Hydrochloric Acid SCHEMBL6712934 | 0.82 | DRD3 (0.56) | HTR1ADRD2DRD3OPRM1HTR7 | |
| SCHEMBL7082370 | 0.82 | DRD3 (0.56) | HTR1ADRD2DRD3OPRM1HTR7 | |
| Hydrochloric Acid SCHEMBL6715836 | 0.81 | DRD3 (0.55) | HTR1ADRD2DRD3OPRM1HTR7 | |
| SCHEMBL2518183 | 0.77 | ADRA1D (0.71) | HTR1ADRD2DRD3HTR2AHTR7 | |
| SCHEMBL14761301 | 0.77 | HTR1A (0.65) | HTR1ADRD2DRD3LMNAHTR2A | |
| SCHEMBL14761873 | 0.77 | HTR1A (0.69) | HTR1ADRD2DRD3LMNAHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135931-A | Antidepressants, psychological disorders, nervous system disorders | AKZO N.V. (NL) | 1992-08-04 | — | — | US | disclosed |
| EP-0462638-A1 | Pyridinylpiperazine derivatives | Akzo Nobel N.V. (NL) | 1991-12-27 | — | — | EP | disclosed |