Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.42 |
| ▸ | APOB | P04114 | 6/20 | 0.40 |
| ▸ | MTTP | P55157 | 5/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 4/20 | 0.38 |
| ▸ | TMPRSS2 | O15393 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6974831 | 0.89 | TMPRSS2 (0.42) | NAMPTAPOBMTTPPAX8TMPRSS2 | |
| SCHEMBL6963054 | 0.88 | PAX8 (0.41) | NAMPTAPOBMTTPPAX8TMPRSS2 | |
| SCHEMBL6974687 | 0.88 | ABCB1 (0.41) | APOBMTTPNPC1KMT2A | |
| SCHEMBL6970162 | 0.84 | NAMPT (0.47) | NAMPTAPOBMTTPPAX8 | |
| SCHEMBL6974345 | 0.84 | MTTP (0.40) | NAMPTAPOBMTTPPAX8TMPRSS2 | |
| SCHEMBL6974662 | 0.84 | EPHX2 (0.45) | NAMPTAPOBMTTPPAX8 | |
| SCHEMBL6963818 | 0.84 | APOB (0.42) | NAMPTAPOBMTTPPAX8TMPRSS2 | |
| SCHEMBL6966377 | 0.84 | APOB (0.44) | NAMPTAPOBMTTPPAX8 | |
| SCHEMBL6962755 | 0.82 | APOB (0.42) | NAMPTAPOBMTTPPAX8TMPRSS2 | |
| SCHEMBL8472959 | 0.81 | ABCB1 (0.39) | NAMPTMTTPNPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | claimed |