Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTTP | P55157 | 9/20 | 0.40 |
| ▸ | APOB | P04114 | 7/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 4/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | TMPRSS2 | O15393 | 2/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6974831 | 0.87 | TMPRSS2 (0.42) | MTTPAPOBPAX8NAMPTTMPRSS2 | |
| SCHEMBL6975568 | 0.87 | MTTP (0.51) | MTTPAPOB | |
| SCHEMBL6963054 | 0.85 | PAX8 (0.41) | MTTPAPOBPAX8NAMPTTMPRSS2 | |
| SCHEMBL6970162 | 0.85 | NAMPT (0.47) | MTTPAPOBPAX8NAMPT | |
| SCHEMBL6974662 | 0.84 | EPHX2 (0.45) | MTTPAPOBPAX8NAMPT | |
| SCHEMBL6963818 | 0.84 | APOB (0.42) | MTTPAPOBPAX8NAMPTTMPRSS2 | |
| SCHEMBL6966377 | 0.84 | APOB (0.44) | MTTPAPOBPAX8NAMPT | |
| SCHEMBL6972481 | 0.84 | NAMPT (0.42) | MTTPAPOBPAX8NAMPTTMPRSS2 | |
| SCHEMBL6969471 | 0.83 | KEAP1 (0.44) | MTTPAPOBNAMPTTMPRSS2FPR2 | |
| SCHEMBL6962755 | 0.82 | APOB (0.42) | MTTPAPOBPAX8NAMPTTMPRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | claimed |