Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.43 |
| ▸ | PPARG | P37231 | 6/20 | 0.43 |
| ▸ | PPARA | Q07869 | 6/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6972309 | 0.94 | KDR (0.52) | KDRFFAR1HPGDPPARGPPARA | |
| SCHEMBL10365493 | 0.86 | HPGD (0.61) | FFAR1HPGDPTPN1PPARGPPARA | |
| SCHEMBL10365494 | 0.86 | HPGD (0.61) | FFAR1HPGDPTPN1PPARGPPARA | |
| SCHEMBL6968087 | 0.85 | KCNH2 (0.56) | KDRFFAR1HPGDPTPN1PPARG | |
| SCHEMBL8128996 | 0.83 | PPARG (0.47) | KDRFFAR1HPGDHDAC4PTPN1 | |
| SCHEMBL8128997 | 0.83 | PPARG (0.47) | KDRFFAR1HPGDHDAC4PTPN1 | |
| SCHEMBL8340675 | 0.82 | KDR (0.57) | KDRFFAR1PTPN1PPARGPPARA | |
| SCHEMBL8340671 | 0.82 | KDR (0.57) | KDRFFAR1PTPN1PPARGPPARA | |
| SCHEMBL10365495 | 0.80 | FFAR1 (0.53) | KDRFFAR1HPGDPTPN1PPARG | |
| SCHEMBL6973022 | 0.79 | PPARG (0.47) | KDRFFAR1HPGDPTPN1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783496-B9 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-09-03 | — | — | EP | disclosed |
| EP-0783496-B1 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-03-26 | — | — | EP | disclosed |
| US-5965589-A | AN ACTIVE MATERIAL HAVING HYPOGLYCEMIC ACTIVITY AND BLOOD LIPID LOWERING ACTIVITY, FOR USE AS AN ANTIDIABETIC AGENT | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-10-12 | — | — | US | disclosed |
| EP-0783496-A1 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996005186-A1 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-02-22 | — | — | WO | disclosed |