Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 7/20 | 0.47 |
| ▸ | PPARA | Q07869 | 6/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8337047 | 1.00 | PPARG (0.47) | PPARGPPARAKDRHPGDFFAR1 | |
| SCHEMBL8336444 | 0.92 | PPARG (0.46) | PPARGPPARAKDRFFAR1MAPT | |
| SCHEMBL8341031 | 0.86 | PPARG (0.54) | PPARGPPARAKDRFFAR1MAPT | |
| SCHEMBL10365494 | 0.84 | HPGD (0.61) | PPARGPPARAHPGDFFAR1PTPN1 | |
| SCHEMBL10365493 | 0.84 | HPGD (0.61) | PPARGPPARAHPGDFFAR1PTPN1 | |
| SCHEMBL8799445 | 0.82 | PPARG (0.45) | PPARGPPARAKDRFFAR1MAPT | |
| SCHEMBL8799441 | 0.82 | PPARG (0.45) | PPARGPPARAKDRFFAR1MAPT | |
| SCHEMBL8128997 | 0.81 | PPARG (0.47) | PPARGPPARAKDRHPGDFFAR1 | |
| SCHEMBL8128996 | 0.81 | PPARG (0.47) | PPARGPPARAKDRHPGDFFAR1 | |
| SCHEMBL6972649 | 0.79 | KDR (0.48) | PPARGPPARAKDRHPGDFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783496-B9 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-09-03 | — | — | EP | disclosed |
| EP-0783496-B1 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-03-26 | — | — | EP | disclosed |
| US-5965589-A | AN ACTIVE MATERIAL HAVING HYPOGLYCEMIC ACTIVITY AND BLOOD LIPID LOWERING ACTIVITY, FOR USE AS AN ANTIDIABETIC AGENT | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-10-12 | — | — | US | disclosed |