Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRB3 | P28472 | 20/20 | 0.52 |
| ▸ | GABRA2 | P47869 | 14/20 | 0.52 |
| ▸ | GABRB2 | P47870 | 14/20 | 0.52 |
| ▸ | GABRP | O00591 | 10/20 | 0.52 |
| ▸ | GABRD | O14764 | 10/20 | 0.52 |
| ▸ | GABRA1 | P14867 | 10/20 | 0.52 |
| ▸ | GABRB1 | P18505 | 10/20 | 0.52 |
| ▸ | GABRG2 | P18507 | 10/20 | 0.52 |
| ▸ | GABRA5 | P31644 | 10/20 | 0.52 |
| ▸ | GABRA3 | P34903 | 10/20 | 0.52 |
| ▸ | GABRA4 | P48169 | 10/20 | 0.52 |
| ▸ | GABRE | P78334 | 10/20 | 0.52 |
| ▸ | GABRA6 | Q16445 | 10/20 | 0.52 |
| ▸ | GABRG1 | Q8N1C3 | 10/20 | 0.52 |
| ▸ | GABRG3 | Q99928 | 10/20 | 0.52 |
| ▸ | GABRQ | Q9UN88 | 10/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2002131 | 0.88 | GABRA2 (0.61) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL7812275 | 0.87 | GABRB3 (0.55) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL7818741 | 0.84 | GABRB3 (0.49) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL2000174 | 0.80 | GABRB3 (0.44) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL6976127 | 0.80 | GABRB3 (0.55) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL2000173 | 0.80 | GABRB3 (0.44) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL7815622 | 0.78 | GABRB3 (0.53) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL6055918 | 0.78 | GABRB3 (0.53) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL337554 | 0.78 | GABRA2 (0.65) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL2839580 | 0.77 | GABRB3 (0.47) | GABRB3GABRA2GABRB2GABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0933363-B1 | Parasiticidal pyrazoles | PFIZER LTD (GB) | 2003-08-27 | — | — | EP | disclosed |
| EP-0946515-B1 | PARASITICIDAL PYRAZOLES | PFIZER LTD (GB) | 2003-03-05 | — | — | EP | disclosed |
| US-20020173662-A1 | Parasiticidal pyrazoles | BANKS BERNARD JOSEPH (GB) | 2002-11-21 | — | — | US | disclosed |
| EP-0871617-B1 | PARASITICIDAL COMPOUNDS | PFIZER (US) | 2001-11-14 | — | — | EP | disclosed |
| US-6268509-B1 | PESTICIDES | PFIZER INC | 2001-07-31 | — | — | US | disclosed |
| US-6255333-B1 | HUMANS OR ANIMALS | PFIZER INC. | 2001-07-03 | — | — | US | disclosed |
| US-6090394-A | FOR HUMANS, ANIMALS | PFIZER INC. (US) | 2000-07-18 | — | — | US | disclosed |
| US-6075043-A | Parasiticidal pyrazoles | PFIZER INC. (US) | 2000-06-13 | — | — | US | disclosed |
| US-6019986-A | Parasiticidal pyrazoles | PFIZER INC. (US) | 2000-02-01 | — | — | US | disclosed |
| EP-0946515-A1 | PARASITICIDAL PYRAZOLES | Pfizer Limited (GB) | 1999-10-06 | — | — | EP | disclosed |
| EP-0933363-A1 | Parasiticidal pyrazoles | Pfizer Limited (GB) | 1999-08-04 | — | — | EP | disclosed |
| EP-0871617-A1 | PARASITICIDAL COMPOUNDS | PFIZER INC. (US) | 1998-10-21 | — | — | EP | disclosed |
| WO-1998024767-A1 | PARASITICIDAL PYRAZOLES | PFIZER LIMITED (GB) | 1998-06-11 | — | — | WO | disclosed |
| WO-1997007102-A1 | PARASITICIDAL COMPOUNDS | PFIZER INC (US) | 1997-02-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020173662-A1 | Parasiticidal pyrazoles | HRH3, HRH2, HRH1 | GABRB3 749/4885GABRA2 535/4885GABRB2 708/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.