Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA2 | P47869 | 20/20 | 0.65 |
| ▸ | GABRB2 | P47870 | 20/20 | 0.65 |
| ▸ | GABRP | O00591 | 19/20 | 0.65 |
| ▸ | GABRD | O14764 | 19/20 | 0.65 |
| ▸ | GABRA1 | P14867 | 19/20 | 0.65 |
| ▸ | GABRB1 | P18505 | 19/20 | 0.65 |
| ▸ | GABRG2 | P18507 | 19/20 | 0.65 |
| ▸ | GABRB3 | P28472 | 19/20 | 0.65 |
| ▸ | GABRA5 | P31644 | 19/20 | 0.65 |
| ▸ | GABRA3 | P34903 | 19/20 | 0.65 |
| ▸ | GABRA4 | P48169 | 19/20 | 0.65 |
| ▸ | GABRE | P78334 | 19/20 | 0.65 |
| ▸ | GABRA6 | Q16445 | 19/20 | 0.65 |
| ▸ | GABRG1 | Q8N1C3 | 19/20 | 0.65 |
| ▸ | GABRG3 | Q99928 | 19/20 | 0.65 |
| ▸ | GABRQ | Q9UN88 | 19/20 | 0.65 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2002131 | 0.88 | GABRA2 (0.61) | GABRA2GABRB2GABRPGABRDGABRA1 | |
| SCHEMBL7812275 | 0.88 | GABRB3 (0.55) | GABRA2GABRB2GABRPGABRDGABRA1 | |
| SCHEMBL8166979 | 0.85 | GABRP (0.58) | GABRA2GABRB2GABRPGABRDGABRA1 | |
| SCHEMBL7805688 | 0.85 | GABRP (0.58) | GABRA2GABRB2GABRPGABRDGABRA1 | |
| SCHEMBL8166981 | 0.85 | GABRP (0.58) | GABRA2GABRB2GABRPGABRDGABRA1 | |
| SCHEMBL13407606 | 0.83 | GABRA2 (0.65) | GABRA2GABRB2GABRPGABRDGABRA1 | |
| SCHEMBL7711441 | 0.82 | GABRA2 (0.52) | GABRA2GABRB2GABRPGABRDGABRA1 | |
| SCHEMBL5729771 | 0.82 | GABRA2 (0.67) | GABRA2GABRB2GABRPGABRDGABRA1 | |
| SCHEMBL7713384 | 0.82 | GABRA2 (0.70) | GABRA2GABRB2GABRPGABRDGABRA1 | |
| SCHEMBL6055658 | 0.82 | GABRP (0.55) | GABRA2GABRB2GABRPGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9334241-B2 | Process for the preparation of N-substituted pyrazole compounds | ROTAM AGROCHEM INTERNATIONAL COMPANY LIMITED (HK) | 2016-05-10 | — | — | US | disclosed |
| US-20140350267-A1 | PROCESS FOR THE PREPARATION OF N-SUBSTITUTED PYRAZOLE COMPOUNDS | ROTAM AGROCHEM INTERNATIONAL COMPANY LIMITED (CN) | 2014-11-27 | — | — | US | disclosed |
| US-8097732-B2 | e.g. 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(1,3-dithiolan-2-yl)-1H-pyrazole-3-carbonitrile; controlling pests, especially by treatment of domestic animals | MERIAL LIMITED (US) | 2012-01-17 | — | — | US | disclosed |
| EP-1824845-B1 | 1-ARYLPYRAZOLES AND THEIR USE AS PESTICIDES | MERIAL LTD (US) | 2011-03-09 | — | — | EP | disclosed |
| US-20080132558-A1 | e.g. 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(1,3-dithiolan-2-yl)-1H-pyrazole-3-carbonitrile; controlling pests, especially by treatment of domestic animals | MERIAL, INC. | 2008-06-05 | — | — | US | disclosed |
| EP-1824845-A1 | 1-ARYLPYRAZOLES AND THEIR USE AS PESTICIDES | Merial Ltd. (US) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006063700-A1 | 1-ARYLPYRAZOLES AND THEIR USE AS PESTICIDES | MERIAL LTD. (US) | 2006-06-22 | — | — | WO | disclosed |
| EP-1671967-A1 | 1-Arylpyrazoles and their use as pesticides | Bayer CropScience S.A. (FR) | 2006-06-21 | — | — | EP | disclosed |
| EP-0918756-B1 | PARASITICIDAL PYRAZOLES | PFIZER LTD (GB) | 2004-02-25 | — | — | EP | disclosed |
| US-6028096-A | Parasiticidal pyrazoles | PFIZER INC (US) | 2000-02-22 | — | — | US | disclosed |
| EP-0918756-A1 | PARASITICIDAL PYRAZOLES | Pfizer Limited (GB) | 1999-06-02 | — | — | EP | disclosed |
| WO-1998004530-A1 | PARASITICIDAL PYRAZOLES | PFIZER LIMITED (GB) | 1998-02-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140350267-A1 | PROCESS FOR THE PREPARATION OF N-SUBSTITUTED PYRAZOLE COMPOUNDS | CBR3, CBR1, POR | GABRA2 1057/4885GABRB2 864/4885GABRP 1826/4885 |
| US-20080132558-A1 | e.g. 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(1,3-dithiolan-2-yl)-1H-pyrazole-3-carbonitrile; controlling pests, especially by treatment of domestic animals | GRK5, HRH4, GRK7 | GABRA2 1429/4885GABRB2 1541/4885GABRP 1870/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.