Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 12/20 | 0.53 |
| ▸ | MMP3 | P08254 | 9/20 | 0.53 |
| ▸ | MMP9 | P14780 | 3/20 | 0.49 |
| ▸ | MMP1 | P03956 | 2/20 | 0.49 |
| ▸ | MMP14 | P50281 | 2/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6434175 | 0.93 | MMP2 (0.54) | MMP2MMP3MMP9MMP1MMP14 | |
| SCHEMBL6959536 | 0.92 | MMP2 (0.51) | MMP2MMP3MMP9MMP1MMP14 | |
| SCHEMBL6433679 | 0.90 | MMP2 (0.51) | MMP2MMP3MMP9MMP1MMP14 | |
| SCHEMBL6433156 | 0.90 | MMP2 (0.51) | MMP2MMP3MMP9MMP1MMP14 | |
| SCHEMBL6437467 | 0.90 | MMP2 (0.51) | MMP2MMP3MMP9MMP1MMP14 | |
| SCHEMBL6971910 | 0.87 | MMP2 (0.63) | MMP2MMP3MMP9MMP1MMP14 | |
| SCHEMBL6959909 | 0.87 | MMP2 (0.51) | MMP2MMP3MMP9MMP1MMP14 | |
| SCHEMBL6586243 | 0.87 | MMP2 (0.49) | MMP2MMP3MMP9MMP1MMP14 | |
| SCHEMBL6587889 | 0.84 | MMP2 (0.65) | MMP2MMP3MMP9MMP1MMP14 | |
| SCHEMBL7415783 | 0.84 | MMP2 (0.65) | MMP2MMP3MMP9MMP1MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1181017-B1 | METALLOPROTEASE INHIBITORS | PFIZER LTD (GB) | 2003-04-16 | — | — | EP | claimed |
| EP-1181017-A1 | METALLOPROTEASE INHIBITORS | Pfizer Limited (GB) | 2002-02-27 | — | — | EP | disclosed |
| WO-2000074681-A1 | METALLOPROTEASE INHIBITORS | PFIZER LIMITED (GB) | 2000-12-14 | — | — | WO | disclosed |