Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6966686 | 1.00 | ESR1 (0.43) | ESR1ESR2NPC1RAB9AMAPT | |
| SCHEMBL6965330 | 0.92 | ESR1 (0.42) | ESR1ESR2NPC1RAB9AMAPT | |
| SCHEMBL6974399 | 0.92 | ESR1 (0.42) | ESR1ESR2NPC1RAB9AMAPT | |
| SCHEMBL6964272 | 0.90 | KMT2A (0.49) | NPC1RAB9AMAPTGAAMEN1 | |
| SCHEMBL6962441 | 0.90 | KMT2A (0.49) | NPC1RAB9AMAPTGAAMEN1 | |
| SCHEMBL6971280 | 0.85 | L3MBTL1 (0.44) | MAPTSMN1; SMN2GAAHRH4HRH3 | |
| SCHEMBL6966124 | 0.83 | ROCK2 (0.47) | NPC1RAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL224352 | 0.81 | DAO (0.41) | SMN1; SMN2MEN1KMT2ALMNAL3MBTL1 | |
| SCHEMBL6960634 | 0.79 | KMT2A (0.50) | NPC1RAB9AMAPTGAAMEN1 | |
| SCHEMBL6961218 | 0.79 | KMT2A (0.50) | NPC1RAB9AMAPTGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729459-B1 | PHENYL-ALKYL IMIDAZOLES AS H3-RECEPTOR ANTAGONISTS | SCHERING CORP (US) | 2003-03-12 | — | — | EP | disclosed |
| US-5578616-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS, TREATMENT FOR GASTROINTESTINAL AND CARDIOVASCULAR DISORDERS | SCHERING CORPORATION (US) | 1996-11-26 | — | — | US | disclosed |