SCHEMBL6973791

SCHEMBL6973791

CC(C)c1nc(CNC(N)=O)n(C)c1Sc1cc(Cl)cc(Cl)c1

nearest known ligand 0.33

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
HSP90B1 P14625 4/20 0.32
TRAP1 Q12931 2/20 0.32
HSP90AA1 P07900 1/20 0.32
HSP90AB1 P08238 1/20 0.32
MALT1 Q9UDY8 1/20 0.32
RECQL P46063 1/20 0.31
DRD2 P14416 1/20 0.30
HTR2A P28223 1/20 0.30
HTR7 P34969 1/20 0.30
HTR6 P50406 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6965470 0.90 SETDB1 (0.33) HSP90B1TRAP1HSP90AA1HSP90AB1MALT1
SCHEMBL6971356 0.89 TP53 (0.38) DRD2HTR2AHTR7HTR6
SCHEMBL6965682 0.88 TSHR (0.35) HSP90B1TRAP1HSP90AA1HSP90AB1RECQL
SCHEMBL6974137 0.87 CYP2C9 (0.32) CYP2C9CYP2C19HSP90B1TRAP1HSP90AA1
SCHEMBL6965334 0.86 PARP1 (0.30)
SCHEMBL6969831 0.86 SIRT1 (0.32) HSP90B1TRAP1HSP90AA1HSP90AB1DRD2
SCHEMBL6969468 0.86 MAPT (0.34) HSP90B1
SCHEMBL6967933 0.84 HSP90B1 (0.33) HSP90B1TRAP1HSP90AA1HSP90AB1DRD2
SCHEMBL6966177 0.84 HSP90B1 (0.32) HSP90B1TRAP1HSP90AA1HSP90AB1
SCHEMBL7084970 0.84 MAPT (0.37) CYP2C9CYP2C19RECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786455-B1 IMIDAZOLE DERIVATIVE SHIONOGI & CO (JP) 2003-12-03 EP disclosed
US-6147097-A METHOD FOR TREATING AIDS SHIONOGI & CO., LTD. (JP) 2000-11-14 US disclosed
US-5910506-A IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC SHIONOGI & CO., LTD. (JP) 1999-06-08 US disclosed
EP-0786455-A1 IMIDAZOLE DERIVATIVE SHIONOGI & CO., LTD. (JP) 1997-07-30 EP disclosed