SCHEMBL6965470

SCHEMBL6965470

CC(=O)NCc1nc(C(C)C)c(Sc2cc(Cl)cc(Cl)c2)n1C

nearest known ligand 0.33

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SETDB1 Q15047 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.32
MALT1 Q9UDY8 1/20 0.32
HSP90B1 P14625 3/20 0.32
POLB P06746 1/20 0.32
ALOX15 P16050 1/20 0.32
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
USP7 Q93009 1/20 0.31
TRAP1 Q12931 2/20 0.31
HSP90AA1 P07900 1/20 0.31
HSP90AB1 P08238 1/20 0.31
L3MBTL1 Q9Y468 2/20 0.31
NOTUM Q6P988 1/20 0.30
HRH4 Q9H3N8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6973791 0.90 CYP2C9 (0.33) MALT1HSP90B1TRAP1HSP90AA1HSP90AB1
SCHEMBL6974325 0.89 TP53 (0.39) SETDB1POLBNPSR1USP7L3MBTL1
SCHEMBL6965682 0.89 TSHR (0.35) SMN1; SMN2HSP90B1POLBRAB9ATRAP1
SCHEMBL6969468 0.87 MAPT (0.34) HSP90B1
SCHEMBL6964218 0.86 SMN1; SMN2 (0.35) SETDB1SMN1; SMN2MALT1HSP90B1POLB
SCHEMBL6961581 0.86 SMN1; SMN2 (0.32) SMN1; SMN2ALOX15NPC1RAB9ANPSR1
SCHEMBL6967933 0.85 HSP90B1 (0.33) HSP90B1TRAP1HSP90AA1HSP90AB1
SCHEMBL6969352 0.84 HSP90B1 (0.31) HSP90B1TRAP1HSP90AA1HSP90AB1
SCHEMBL6960253 0.83 PTGDR2 (0.32) HSP90B1USP7TRAP1HSP90AA1HSP90AB1
SCHEMBL7084094 0.83 SMN1; SMN2 (0.40) SETDB1SMN1; SMN2POLBNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786455-B1 IMIDAZOLE DERIVATIVE SHIONOGI & CO (JP) 2003-12-03 EP disclosed
US-6147097-A METHOD FOR TREATING AIDS SHIONOGI & CO., LTD. (JP) 2000-11-14 US disclosed
US-5910506-A IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC SHIONOGI & CO., LTD. (JP) 1999-06-08 US disclosed
EP-0786455-A1 IMIDAZOLE DERIVATIVE SHIONOGI & CO., LTD. (JP) 1997-07-30 EP disclosed