Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | PKM | P14618 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30230013 | 0.81 | P2RX1 (0.48) | LMNAHPGDPKMCYP2C9HTT | |
| SCHEMBL15772389 | 0.79 | MAPT (0.70) | LMNAHPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL6977966 | 0.79 | MAPT (0.70) | LMNAHPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL16353893 | 0.78 | MAPT (0.68) | LMNAHPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL16469334 | 0.78 | ALDH1A1 (0.49) | LMNAHPGDALDH1A1HTTPOLB | |
| SCHEMBL15359749 | 0.78 | PTK2B (0.50) | LMNAHPGDPKMALDH1A1HTT | |
| SCHEMBL6978287 | 0.76 | CYP2C9 (0.64) | LMNAHPGDPKMKMT2AALDH1A1 | |
| SCHEMBL6979884 | 0.76 | PLAU (0.53) | LMNAHPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL6971665 | 0.76 | HTT (0.54) | LMNAHPGDPKMMEN1KMT2A | |
| SCHEMBL12492782 | 0.75 | VCAM1 (0.61) | HPGDPKMALDH1A1CYP1A2GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109560-B1 | COMPOUNDS USEFUL AS AICARFT INHIBITORS | AGOURON PHARMA (US) | 2003-08-27 | — | — | EP | disclosed |
| US-6525050-B1 | Inhibit the enzyme aminoimidazole carboxamide ribonucleotide formyl transferase; antiproliferative agents; antitumor, antiinflammatory, antipsoriatic, and/or immunosuppressive | AGOURON PHARMACEUTICALS, INC. | 2003-02-25 | — | — | US | disclosed |