Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | HAT1 | O14929 | 2/20 | 0.50 |
| ▸ | EP300 | Q09472 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | AHR | P35869 | 2/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.46 |
| ▸ | WNT3A | P56704 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.46 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27216649 | 0.83 | GPR84 (0.59) | GPR84TP53SMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL6840316 | 0.83 | NAPRT (0.53) | GPR84TP53SMN1; SMN2NPSR1HAT1 | |
| SCHEMBL699561 | 0.82 | NAPRT (0.41) | GPR84TP53SMN1; SMN2NPSR1HAT1 | |
| SCHEMBL858716 | 0.81 | MAP2K1 (0.53) | GPR84SMN1; SMN2KMT2ANAPRT | |
| SCHEMBL6705760 | 0.81 | GPR84 (0.69) | GPR84TP53SMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL21448966 | 0.78 | MAPT (0.61) | GPR84TP53SMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL700094 | 0.77 | GPR84 (0.63) | GPR84TP53SMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL3279652 | 0.77 | GPR84 (0.79) | GPR84TP53SMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL29988308 | 0.77 | GPR84 (0.79) | GPR84TP53SMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL2028344 | 0.77 | GPR84 (1.00) | GPR84TP53SMN1; SMN2NPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421823-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica N.V. (BE) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010124086-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | disclosed |