Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLNR | O43193 | 1/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6960871 | 0.80 | ALDH1A1 (0.40) | DHFRDRD3ALDH1A1TSHRDRD2 | |
| SCHEMBL6963099 | 0.75 | PRMT5 (0.41) | DHFRDRD3DRD2DRD4PRMT5 | |
| SCHEMBL6972430 | 0.75 | DRD2 (0.53) | DHFRDRD3DRD2CA9KMT2A | |
| SCHEMBL6972852 | 0.73 | DRD2 (0.57) | TSHRDRD2DRD4HTR2BTMEM97 | |
| SCHEMBL1950594 | 0.73 | HRH3 (0.50) | DRD3DRD2KDM4EGAAMAPT | |
| SCHEMBL6970695 | 0.73 | DRD4 (0.46) | DHFRDRD3ALDH1A1DRD2KDM4E | |
| SCHEMBL6973388 | 0.72 | TMEM97 (0.60) | DHFRDRD3DRD2KMT2ACHRM2 | |
| SCHEMBL21412686 | 0.71 | DRD2 (0.44) | DRD3DRD2HSD17B3 | |
| SCHEMBL1953020 | 0.71 | DRD2 (0.46) | DRD3DRD2HTR1AHTR2BSIGMAR1 | |
| SCHEMBL21412795 | 0.71 | SIGMAR1 (0.59) | DRD3DRD2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1181954-A2 | Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (ApoB) secretion | PFIZER INC. (US) | 2002-02-27 | — | — | EP | disclosed |