Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TSPO | P30536 | 1/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.38 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2233053 | 0.85 | ALDH1A1 (0.69) | ALDH1A1TRPM8NPC1RAB9ALMNA | |
| SCHEMBL6968865 | 0.83 | NPC1 (0.44) | ALDH1A1NPC1RAB9AMAPTMAOB | |
| SCHEMBL10165853 | 0.79 | TSHR (0.50) | ALDH1A1NPC1RAB9AMAPTL3MBTL1 | |
| SCHEMBL10381434 | 0.77 | ALDH1A1 (0.56) | ALDH1A1TRPM8NPC1RAB9ALMNA | |
| SCHEMBL7230861 | 0.74 | ALDH1A1 (0.54) | ALDH1A1LMNAMAPTL3MBTL1TSHR | |
| SCHEMBL2290221 | 0.73 | SMN1; SMN2 (0.51) | ALDH1A1NPC1RAB9AMAPTL3MBTL1 | |
| SCHEMBL15020824 | 0.73 | ALDH1A1 (0.46) | ALDH1A1TRPM8NPC1RAB9ALMNA | |
| SCHEMBL5446199 | 0.73 | ALDH1A1 (0.46) | ALDH1A1NPC1MAPTL3MBTL1TSHR | |
| SCHEMBL21026913 | 0.72 | ALDH1A1 (0.50) | ALDH1A1NPC1RAB9AMAPTL3MBTL1 | |
| SCHEMBL4998340 | 0.72 | NPC1 (0.47) | ALDH1A1NPC1RAB9AMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| CN-1093535-C | Imidazole derivative | SHIONOGI & CO (JP) | 2002-10-30 | — | — | CN | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| CN-1158609-A | Imidazole derivative | SHIONOGI & CO (JP) | 1997-09-03 | — | — | CN | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |