Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP8 | P40818 | 1/20 | 0.39 |
| ▸ | FADS1 | O60427 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ITK | Q08881 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6974868 | 0.80 | TTK (0.50) | TTKSMN1; SMN2LRRK2ALDH1A1HTT | |
| SCHEMBL4740564 | 0.78 | SMN1; SMN2 (0.56) | TTKSMN1; SMN2TP53ALDH1A1HTT | |
| SCHEMBL6975273 | 0.77 | MAPT (0.51) | TTKSMN1; SMN2TP53LRRK2ALDH1A1 | |
| SCHEMBL6970859 | 0.76 | SMN1; SMN2 (0.49) | TTKSMN1; SMN2LRRK2HTR6ALDH1A1 | |
| SCHEMBL6966594 | 0.76 | TTK (0.46) | TTKSMN1; SMN2LRRK2HTTKMT2A | |
| SCHEMBL7082179 | 0.76 | TTK (0.47) | TTKHTR6ALDH1A1HTR2AKMT2A | |
| SCHEMBL6978830 | 0.74 | TTK (0.44) | TTKSMN1; SMN2LRRK2HTR6HTT | |
| SCHEMBL6977777 | 0.74 | PRKAG1 (0.46) | TTKALDH1A1KMT2AMEN1CNR2 | |
| SCHEMBL6979256 | 0.74 | FADS1 (0.45) | TTKLRRK2FADS1CNR2GAA | |
| SCHEMBL6978269 | 0.73 | MAPT (0.50) | TTKSMN1; SMN2TP53HTR6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077947-B1 | NOVEL 1,5 AND 3-O-SUBSTITUTED 1H-INDAZOLES WITH ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY, IMMUNO-MODULATING AND NEURO-PROTECTIVE EFFECT, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | DRESDEN ARZNEIMITTEL (DE) | 2003-09-03 | — | — | EP | disclosed |
| US-6166023-A | 1,5- and 3-O-substituted 1H-indazoles having anti-asthmatic, anti-allergic, anti-inflammatory, immunomodulating and neuroprotective action, process for their preparation and their use as medicaments | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 2000-12-26 | — | — | US | disclosed |