Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | HTR3A | P46098 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6975713 | 0.80 | ALDH1A1 (0.56) | MAPTALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6965680 | 0.79 | POLB (0.42) | CHRNA7MAPTALDH1A1CYP2C19KDM4E | |
| SCHEMBL6962643 | 0.78 | ACACB (0.51) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL6965749 | 0.77 | DHFR (0.55) | MAPTALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6964021 | 0.75 | PDE4B (0.52) | ALDH1A1L3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL6973388 | 0.74 | TMEM97 (0.60) | MEN1KMT2AHTR1ADRD3DRD2 | |
| SCHEMBL6976524 | 0.73 | DHFR (0.46) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL6966204 | 0.72 | TMEM97 (0.55) | L3MBTL1MEN1KMT2AHTR1ADRD3 | |
| SCHEMBL15610701 | 0.72 | ALDH1A1 (0.59) | MAPTALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6972464 | 0.72 | SIGMAR1 (0.52) | MAPTALDH1A1L3MBTL1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | disclosed |