Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR8 | P51685 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 6/20 | 0.36 |
| ▸ | HTR1D | P28221 | 6/20 | 0.36 |
| ▸ | HTR1B | P28222 | 6/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SCN1A | P35498 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6972423 | 1.00 | CCR8 (0.43) | CCR8KCNH2DRD2HTR1AHTR1D | |
| SCHEMBL6970280 | 0.98 | CCR8 (0.44) | CCR8KCNH2DRD2HTR1AHTR1D | |
| SCHEMBL6969343 | 0.96 | CCR8 (0.42) | CCR8KCNH2DRD2HTR1AHTR1D | |
| SCHEMBL6968017 | 0.93 | CCR8 (0.44) | CCR8KCNH2DRD2HTR1AKDM4E | |
| SCHEMBL6966012 | 0.91 | CCR8 (0.42) | CCR8KCNH2DRD2HTR1AKDM4E | |
| SCHEMBL6971729 | 0.89 | CCR8 (0.52) | CCR8KCNH2HTR1AKDM4ECYP3A4 | |
| SCHEMBL6978601 | 0.87 | CCR8 (0.39) | CCR8KCNH2KDM4ECYP3A4CYP2D6 | |
| SCHEMBL8131415 | 0.87 | SIGMAR1 (0.44) | CCR8DRD2HTR1AHRH3 | |
| SCHEMBL6977691 | 0.85 | CCR8 (0.40) | CCR8KCNH2CYP3A4 | |
| SCHEMBL6968475 | 0.85 | KCNH2 (0.46) | KCNH2SCN1ASCN2ASCN3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051413-B1 | QUINOLINE DERIVATIVES AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2003-06-04 | — | — | EP | claimed |
| EP-1051413-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-15 | — | — | EP | claimed |
| WO-1999037635-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 1999-07-29 | — | — | WO | claimed |
| EP-1051413-B1 | QUINOLINE DERIVATIVES AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2003-06-04 | — | — | EP | disclosed |
| EP-1051413-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-15 | — | — | EP | disclosed |
| WO-1999037635-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 1999-07-29 | — | — | WO | disclosed |