Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 14/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 10/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | CCR3 | P51677 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6967490 | 0.88 | OPRD1 (0.41) | OPRD1OPRK1ADRA1AADRA2AADRA2B | |
| SCHEMBL6975845 | 0.88 | ADRA1A (0.42) | OPRD1OPRK1ADRA1AADRA2AADRA2B | |
| SCHEMBL6979779 | 0.88 | ADRA1A (0.41) | OPRD1OPRK1ADRA1AADRA2AADRA2B | |
| SCHEMBL6974540 | 0.88 | OPRD1 (0.40) | OPRD1OPRK1ADRA1AADRA2AADRA2B | |
| SCHEMBL6981273 | 0.87 | OPRD1 (0.40) | OPRD1OPRK1ADRA1AADRA2AADRA2B | |
| SCHEMBL6975294 | 0.87 | ADRA1A (0.47) | OPRD1OPRK1ADRA1AADRA2AADRA2B | |
| SCHEMBL6972078 | 0.87 | OPRL1 (0.45) | OPRD1OPRK1ADRA1AADRA2AADRA2B | |
| SCHEMBL6971168 | 0.85 | ADRA1A (0.44) | OPRD1OPRK1ADRA1AADRA2AADRA2B | |
| SCHEMBL6965116 | 0.85 | ADRA1A (0.49) | OPRD1OPRK1ADRA1AADRA2AADRA2B | |
| SCHEMBL6974465 | 0.85 | ALDH1A1 (0.44) | ADRA1AADRA2AADRA2BADRA2CADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | claimed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | claimed |
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | disclosed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | disclosed |