Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6969225 | 0.85 | MAPT (0.33) | MAPTHTTNPSR1SMN1; SMN2 | |
| SCHEMBL6974360 | 0.85 | — | — | |
| SCHEMBL6970027 | 0.83 | KDM4E (0.37) | — | |
| SCHEMBL6970030 | 0.83 | KDM4E (0.37) | — | |
| SCHEMBL6964200 | 0.82 | MAPT (0.37) | MAPTHTTNPSR1HPGDPOLB | |
| SCHEMBL6165204 | 0.81 | NOTUM (0.31) | NOTUM | |
| SCHEMBL6965624 | 0.78 | NPSR1 (0.36) | MAPTHTTNPSR1HPGDNOTUM | |
| SCHEMBL6967902 | 0.78 | NPSR1 (0.39) | MAPTHTTNPSR1HPGDSMN1; SMN2 | |
| SCHEMBL6965342 | 0.75 | NOTUM (0.31) | POLBSMN1; SMN2NOTUM | |
| SCHEMBL6964074 | 0.74 | HSP90AA1 (0.42) | MAPTHTTNPSR1HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |