Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | TERT | O14746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6162368 | 0.88 | DRD2 (0.32) | DRD2HTR2AHTR7HTR6 | |
| SCHEMBL6967902 | 0.87 | NPSR1 (0.39) | MAPTHTTSMN1; SMN2NPSR1NOD2 | |
| SCHEMBL6973184 | 0.86 | DRD2 (0.32) | DRD2HTR2AHTR7HTR6 | |
| SCHEMBL6974766 | 0.85 | MAPT (0.34) | MAPTHTTSMN1; SMN2NPSR1 | |
| SCHEMBL6974360 | 0.84 | — | — | |
| SCHEMBL6969836 | 0.83 | HSP90B1 (0.32) | — | |
| SCHEMBL7086393 | 0.83 | KDM4E (0.36) | DRD2HTR2AHTR7HTR6 | |
| SCHEMBL7086394 | 0.83 | KDM4E (0.36) | DRD2HTR2AHTR7HTR6 | |
| SCHEMBL6964200 | 0.81 | MAPT (0.37) | MAPTHTTSMN1; SMN2NPSR1NOD2 | |
| SCHEMBL6966628 | 0.80 | DRD2 (0.34) | DRD2HTR2AHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |