SCHEMBL6964200

SCHEMBL6964200

CC(C)c1nc(C=O)n(C)c1Sc1ccccc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.37
HTT P42858 5/20 0.37
NPSR1 Q6W5P4 5/20 0.37
SMN1; SMN2 Q16637 4/20 0.37
POLB P06746 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
LMNA P02545 2/20 0.36
NOD2 Q9HC29 1/20 0.36
ALDH1A1 P00352 3/20 0.36
HPGD P15428 2/20 0.36
MAOA P21397 1/20 0.35
MAOB P27338 1/20 0.35
PTPN1 P18031 1/20 0.33
CDC25A P30304 1/20 0.33
CDC25B P30305 1/20 0.33
KDM4E B2RXH2 1/20 0.33
RXFP1 Q9HBX9 1/20 0.33
PKM P14618 1/20 0.31
DHFR P00374 1/20 0.30
PTGDR2 Q9Y5Y4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6965624 0.84 NPSR1 (0.36) MAPTHTTNPSR1ALDH1A1HPGD
SCHEMBL6967902 0.84 NPSR1 (0.39) MAPTHTTNPSR1SMN1; SMN2L3MBTL1
SCHEMBL7078798 0.82 KDM4E (0.47) MAPTHTTNPSR1SMN1; SMN2POLB
SCHEMBL6969032 0.82 KDM4E (0.33) MAPTHTTNPSR1SMN1; SMN2POLB
SCHEMBL7078796 0.82 KDM4E (0.47) MAPTHTTNPSR1SMN1; SMN2POLB
SCHEMBL6974766 0.82 MAPT (0.34) MAPTHTTNPSR1SMN1; SMN2POLB
SCHEMBL6964074 0.81 HSP90AA1 (0.42) MAPTHTTNPSR1SMN1; SMN2POLB
SCHEMBL6969225 0.81 MAPT (0.33) MAPTHTTNPSR1SMN1; SMN2NOD2
SCHEMBL6974360 0.81
SCHEMBL6973949 0.77 MAPT (0.39) MAPTHTTNPSR1SMN1; SMN2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786455-B1 IMIDAZOLE DERIVATIVE SHIONOGI & CO (JP) 2003-12-03 EP disclosed
US-6147097-A METHOD FOR TREATING AIDS SHIONOGI & CO., LTD. (JP) 2000-11-14 US disclosed
US-5910506-A IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC SHIONOGI & CO., LTD. (JP) 1999-06-08 US disclosed